One patient was diagnosed with two new ADs. Results: Twenty-one patients have been diagnosed with a new ID, 10 of them with an AD (autoimmune thyroid disease, psoriasis, rheumatoid arthritis, transverse myelitis, granuloma annulare, primary biliary cirrhosis, alopecia areata and antiphospholipid syndrome), and 11 with other IDs (allergic rhinitis, allergic asthma, atopic dermatitis, food allergy, contact dermatitis and drug allergy). The diagnosis of narcolepsy was made according to the International Classification of Sleep Disorders (ICSD-3). All but one case (familial case) were HLA-DQB1*06:02-positive. Methods: A longitudinal observational study was conducted over 6 years (2014 - 2020) in a series of 158 Caucasians NT1 patients (96 males mean age: 50.1 ± 19.0 years) from the previous study. Short title: Outcome of NT1 Patients With ADs and IDsīackground: The aim of this study was to evaluate the long-term outcome of our series of narcolepsy type 1 (NT1) patients with comorbid autoimmune diseases (ADs) and other immunopathological diseases (IDs), focusing on the incidence of new ADs and IDs in this sample. Manuscript submitted June 5, 2022, accepted August 11, 2022, published online August 27, 2022 Vicario c, Laura Lillo-Triguero d, Elena Ameyugo a, Rosa Peraita-Adrados e, fĪSleep Unit, Clinical Neurophysiology Service, San Carlos University Hospital, University Complutense of Madrid, SpainīImmunology Service, San Carlos University Hospital, University Complutense of Madrid, SpainĬHistocompatibility, Blood Center of the Community of Madrid, SpainĭNeurology and Sleep Unit, Ruber International Hospital, Madrid, SpainĮSleep and Epilepsy Unit, Clinical Neurophysiology Service, University General Hospital and Research Institute Gregorio Maranon, University Complutense of Madrid, SpainįCorresponding Author: Rosa Peraita-Adrados, Sleep and Epilepsy Unit, Clinical Neurophysiology Service, University General Hospital and Research Institute Gregorio Maranon, University Complutense of Madrid (UCM), Madrid 28007, Spain Martinez-Orozco a, Miguel Fernandez-Arquero b, Jose L.
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